High-Content Screening of Natural Products Reveals Novel Nuclear Export Inhibitors
نویسندگان
چکیده
منابع مشابه
High-content screening identifies inhibitors of the nuclear translocation of ATF6.
Activating transcription factor 6 (ATF6) is a transmembrane protein that consists of a cytoplasmic domain and an endoplasmic reticulum (ER) luminal domain. As unfolded protein levels arise in the ER, the ER cytoplasmic domain of ATF6 moves to the nucleus, where it activates the transcription of a range of genes, including those involved in apoptosis. As ATF6 only becomes functional once it has ...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Screening
سال: 2013
ISSN: 1087-0571,1552-454X
DOI: 10.1177/1087057113501389